AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes
M‑89MedChemExpress (MCE)美国M-89 是一种强效的、特异性的 menin 的抑制剂,结合到 menin 的 Kd 值为 1.4 nM。M-89 可抑制 Menin-MLL 蛋白之间的相互作用,有研究混合谱系白血病的
(N-Methylamino)-9,10-anthraquinone|5O1807MLL1|UNII-5O1807MLL1|CS-0010137|InChI=1/C15H11NO2/c1-16-12-8-4-7-11-13(12)15(18
methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL
(WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.体外活性: MM-589 inhibits cell growth in human
domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.体外活性: MM-589 inhibits cell growth
OICR-0547MedChemExpress (MCE)美国OICR-0547 是阴性对照物,是与 OICR-9429 (HY-16993) 密切相关的衍生产品。OICR-9429 是 Wdr5-MLL 相互作用的新型小分子拮抗剂,而
G1 期。BRD4-IN-4可用于 MLL 白血病的研究。BRD4-IN-4 (Compound 1) 是一种 BRD4 抑制剂 (IC50=6.83 μM)。BRD4-IN-4 选择性抑制 MV4-11 细胞系增殖并将细胞阻滞在 G1 期
to their respective KM values.体外活性: EPZ004777对MLL白血病小鼠移植瘤模型产生有效的抗肿瘤功效,且平均寿命显著延长.体内活性: 在抑制DOT1L后,EPZ004777选择性抑制MLL重排细胞系和MLL-AF9转化的鼠造血
by the MLL-AF9 translocation (IC50 of 26 µM). In THP1 cells, SW2_110A (100 µM; 24h) treatment results in a significant decrease
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