or β3 subunit-containing GABAA receptors. Etifoxine exhibits anxiolytic activity in rodents and humans with no sedative
hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.
and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents
xenograft model in mouse, and also acceptable pharmacokinetic dosing in dog, monkey and rodents, on target efficacy, as well
pouch models. More recently carrageenan has been injected directly into the joints of rodents to model arthritic pain
expression in NOMO1 cells. I-BET151 improves survival in two rodents models of MLL-fusion leukemia in vivo.
administration to rodents elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain. LY2183240
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